Generals Hwy - CA
Driving high up into the Sequoia Mountains and Kings Canyon National park runs CA-180 and CA-198. With several tourist destinations along the route, there can be traffic and the occasional park ranger with a radar, BUT that isn't enough to keep this road off our list. With hundreds of turns, thousands of feet of elevation change and views worth a million bucks, this is a road you have to hit!
By the way, mid point along the route, don't forgot to stop and make the short hike up to Moro Rock for an unforgettable Sierra Nevada vista. Also consider stopping to see General Sherman, the largest tree in the world!